By plane
The airport IATA: PIU has flights to Chiclayo and Lima. Airlines come and go frequently, LAN (http://www.lan.com) seems to have the strongest hold. TACA also has cheap flights to Lima. Flights leave around 6:30am, 2:00pm, and another later in the evening.
By bus
National buses run along the Panamerican Highway from Lima to Tumbes 4.5 hours & some to the border with Ecuador.Ormeño (http://www.grupo-ormeno.com) Lima to Guayaquil daily & Quito weekly, & Transportes Loja Piura to Loja 3 times daily, US$10, 8-9 hours, have international buses to Ecuador.CIFA has buses to Guayaquil with connections to Cuenca via Machala. The "Especial" service is a double decker bus with sleeper seats on the lower floor. Cuenca 12-15$, 10 hours.
Transportes Linea (http://www.transporteslin...) and Oltursa (http://www.oltursa.com.pe) have frequent buses to Chiclayo, Trujillo and to Lima.
ITTSA (http://www.ittsabus.com/) has luxury buses to:Trujillo 6 hours 25/35 Soles in Semi-cama/Sofa-Cama,Chiclayo 2.5 hours,Lima 15 hours.
Bus lines that run to the north include El Dorado, EPPO, and El Sol. There are frequent combis north to Mancora.